Our tests are based on data from the INSERM UMR 1296 radiobiology unit in Lyon, gathered from an important collection of radiosensitive patients’ human cells. ATM: the key protein The researchers have shown that a key stress response protein called ATM (“Ataxia Telangiectasia Mutated”) shuttles in the cell nucleus to trigger the repair of DNA damage. Any absence or delay of this protein leads to a specific level of radiosensitivity. Development of two biological tests Neolys Diagnostics developed a range of tests based on this protein. With a patient’s sample (blood/skin/tumor), these tests define the therapeutic window which is specific to each patient. They are therefore invaluable decision-making tools for physicians.
Proof of Concept of a Binary Blood Assay for Predicting Radiosensitivity.
CANCERS (BASEL). 2021 MAY 19;13(10):2477. DOI: 10.3390/CANCERS13102477. PMID: 34069662; PMCID: PMC8160794. Deneuve S, Bastogne T, Duclos M, Mirjolet C, Bois P, Bachmann P, Nokovitch L, Roux PE, Girodet D, Poupart M, Zrounba P, Claude L, Ferella L, Iacovelli NA, Foray N, Rancati T, Pereira S